Classical and Modern Drug Treatments for Leishmaniasis.- Saponins as Potential Antiprotozoa Agents.- Chagas Disease: Drug Development and Parasite Target.- Targeting carbonic anhydrases from Leishmania spp. and Trypanosoma cruzi as a strategy to obtain new drugs.- New Compounds for the Management of Trypanosoma brucei Infection.- Polyamine and Trypanothione Pathways as Targets for Novel Antileishmanial Drugs.- Nano and Microstructured Delivery Systems for Current Antileishmanial Drugs.- Pharmacological Treatment of Malaria.- η-Class Carbonic Anhydrases as Antiplasmodial Drug Targets: Current State of the Art and Hurdles to Develop New Antimalarials.- Management of Entamoeba histolytica Infection: Treatment Strategies and Possible New Drug Targets.- Trichomonas vaginalis Pharmacological Treatment.- Beta-Carbonic Anhydrase from Trichomonas Vaginalis as New Antiprotozoan Drug Target.- Drugs for the treatment of toxoplasmosis.- Challenges and promises for obtaining new antiprotozoal drugs - what's going wrong?