Emphasizing mass spectrometry, this book provides strategies and concepts for understanding and analyzing chemical proteomics, their functions, modifications, and interactions. Chapters cover technical advances and applications in drug discovery, from target identification to validation and potential treatments.
- Provides a basic overview of chemical proteomics, up-to-date concepts, analysis, and target validation
- Covers fundamentals and strategies, including proteome profiling and chemical probes
- Explains technical advances in the field and describes on shotgun proteomics, protein profiling, quantitative proteomics, peptide biosensors, and glycoprotein analysis
- Includes a wide variety of applications in drug discovery, from drug targets to the chemoproteomics analysis of natural products
W. ANDY TAO, PHD, is a Professor in the Department of Biochemistry at Purdue University. He is also the Founder and Chief Scientific Officer at Tymora Analytical Operations, LLC, which provides lab R&D products for life sciences. Dr. Tao is the recipient of awards, such as the American Society of Mass Spectrometry Research Award, and author of more than 140 articles and book chapters on proteomics and mass spectrometry. YING ZHANG, PHD, is a Professor at Fudan University. Her research focuses on the development of mass spectrometry-based new approaches for the analysis of low abundant proteins and posttranslational proteins.